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Home / 2025 Mercedes-Benz S 500 4MATIC® vs 2025 Mercedes-Benz S 580 4MATIC® Sedan

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan

front view of the 2025 Mercedes-Benz S-Class Sedan

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan Comparison


The 2025 Mercedes-Benz S-Class continues to set the gold standard in luxury sedans, blending innovation, power, and elegance. Among its prestigious lineup, the S 500 4MATIC® and S 580 4MATIC® stand out as remarkable options for those seeking sophistication with exhilarating performance. While both sedans showcase cutting-edge technology, refined comfort, and impeccable craftsmanship, they cater to distinct driving preferences. At Mercedes-Benz of Scottsdale in Scottsdale, AZ, our team has put together a 2025 Mercedes-Benz S 500 4MATIC® vs 2025 Mercedes-Benz S 580 4MATIC® Sedan comparison for you to make an informed decision.

Latest Mercedes-Benz CLE at MB of Scottsdale

2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$128,355
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2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$133,490
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2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$134,335
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2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$139,780
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2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$140,830
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$141,815
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$145,965
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$146,865
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$147,495
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$150,295
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$150,455
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$154,510
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$156,105
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Mercedes-Benz S-Class Inventory Reach Out to Us!

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan: Which Model is Right for You?

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan: Performance & Powertrain  


Under the hood, the S 500 4MATIC® boasts a 3.0L inline-6 turbo engine with mild hybrid drive, delivering 442 horsepower and 413 lb-ft of torque. This electrified powertrain enhances fuel efficiency while ensuring seamless acceleration. In contrast, the S 580 4MATIC® steps up with a 4.0L V8 biturbo engine, producing an impressive 496 horsepower and 516 lb-ft of torque. With its enhanced output and 0-60 mph time of just 4.3 seconds, the S 580 offers a more exhilarating driving experience for those craving extra power.

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan: Design & Styling

Both sedans exude modern elegance, with AMG body styling available to enhance their bold presence. The Night Package, standard on both models, adds jet-black accents for extra sportiness. Distinctive all-LED exterior lighting and a wraparound taillamp design amplify their sophisticated road presence.

front view of the 2025 Mercedes-Benz S-Class Sedan with all LED exterior lighting
steering wheel of the 2025 Mercedes-Benz S-Class Sedan

2025 Mercedes-Benz S 500 4MATIC® vs. 2025 Mercedes-Benz S 580 4MATIC® Sedan: Interior Comfort & Technology

Step inside either model and find a cabin designed for unparalleled comfort. Heated 12-way power front seats with memory, active multicontour seats with massage functions, and ENERGIZING kinetics ensure a first-class experience. Their 12.8-inch OLED touchscreen multimedia displays and 12.3-inch digital instrument clusters provide intuitive control and immersive infotainment. The S 580 4MATIC®, however, offers an optional 3D instrument cluster for a more dynamic driving interface.

Which S-Class Sedan Is Right for You?

While the S 500 4MATIC® is ideal for those who appreciate refined efficiency and effortless power, the S 580 4MATIC® caters to drivers who demand exhilarating performance and a more commanding presence. No matter your preference, both sedans embody the pinnacle of Mercedes-Benz luxury. If you want to explore the features of S-class sedans, you can schedule a test drive in Scottsdale, AZ, or visit us at Mercedes-Benz of Scottsdale.

Interested in the 2025 Mercedes-Benz S-Class?

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2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
4 Interested, Scottsdale, AZ, 3.0L I6 Turbo -inc: mild-hybrid system and ECO start/stop system, S 500 4MATIC® Sedan, Automatic, # M25921, 9G-TRONIC Automatic, All Wheel Drive, 21/31 mpg
Engine 3.0L I6 Turbo -inc: mild-hybrid system and ECO start/stop system
Transmission Description 9G-TRONIC Automatic
Drivetrain All Wheel Drive
Fuel Economy 21/31
MSRP
$128,355
DetailsShow selling price
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
23 Interested, Scottsdale, AZ, 3.0L I6 Turbo -inc: mild-hybrid system and ECO start/stop system, S 500 4MATIC® Sedan, Automatic, # M25780, 9G-TRONIC Automatic, All Wheel Drive, 21/31 mpg
Engine 3.0L I6 Turbo -inc: mild-hybrid system and ECO start/stop system
Transmission Description 9G-TRONIC Automatic
Drivetrain All Wheel Drive
Fuel Economy 21/31
MSRP
$133,490
DetailsShow selling price
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
4 Interested, Scottsdale, AZ, 3.0L I6 Turbo Engine, S 500 4MATIC® Sedan, Automatic, # M25896, 9G-TRONIC Automatic, All Wheel Drive, 21/31 mpg
Engine 3.0L I6 Turbo Engine
Transmission Description 9G-TRONIC Automatic
Drivetrain All Wheel Drive
Fuel Economy 21/31
MSRP
$134,335
DetailsShow selling price
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
104 Interested, Peoria, AZ, 4.0L V8 Biturbo Mild-Hybrid Engine, S 580 4MATIC® Sedan, Automatic, # A17646, All Wheel Drive, 17/25 mpg
Engine 4.0L V8 Biturbo Mild-Hybrid Engine
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$139,780
DetailsShow selling price
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
16 Interested, Peoria, AZ, 4.0L V8 Biturbo Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # A18019, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L V8 Biturbo Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$140,830
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
29 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25830, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$141,815
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
18 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25831, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$145,965
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
4 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25886, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$146,865
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
24 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25773, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$147,495
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
78 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25789, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$150,295
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
8 Interested, Peoria, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # A18084, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$150,455
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
14 Interested, Peoria, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # A18078, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$154,510
DetailsShow selling price
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
6 Interested, Scottsdale, AZ, 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system, S 580 4MATIC® Sedan, Automatic, # M25871, 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT, All Wheel Drive, 17/25 mpg
Engine 4.0L Twin-Turbo V8 Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
Fuel Economy 17/25
MSRP
$156,105
DetailsShow selling price
2025 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2025 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
93 Interested, Peoria, AZ, P3 Hybrid Handcrafted AMG 4.0L V8 Bi-Turbo Engine, AMG® S 63 E 4MATIC® Sedan, Automatic, # A17647, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG 4.0L V8 Bi-Turbo Engine
Drivetrain All Wheel Drive
MSRP
$201,150
DetailsShow selling price
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
6 Interested, Scottsdale, AZ, P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system, AMG® S 63 E 4MATIC® Sedan, Automatic, # M25887, AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system
Transmission Description AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
MSRP
$201,275
DetailsShow selling price
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
78 Interested, Scottsdale, AZ, P3 Hybrid Handcrafted AMG 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system, AMG® S 63 E 4MATIC® Sedan, Automatic, # M25731, AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system
Transmission Description AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
MSRP
$202,165
DetailsShow selling price
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
10 Interested, Peoria, AZ, P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system, AMG® S 63 E 4MATIC® Sedan, Automatic, # A18079, AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system
Transmission Description AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
MSRP
$211,255
DetailsShow selling price
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
68 Interested, Scottsdale, AZ, P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system, AMG® S 63 E 4MATIC® Sedan, Automatic, # M25805, AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system
Transmission Description AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
MSRP
$221,835
DetailsShow selling price
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
2026 Mercedes-Benz S-Class AMG® S 63 E 4MATIC® Sedan
198 Interested, Scottsdale, AZ, P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system, AMG® S 63 E 4MATIC® Sedan, Automatic, # M25794, AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT, All Wheel Drive
Engine P3 Hybrid Handcrafted AMG® 4.0L V8 Bi-Turbo -inc: permanently-excited synchronous electric motor and ECO start/stop system
Transmission Description AMG® SPEEDSHIFT MCT 9G Automatic -inc: DYNAMIC SELECT
Drivetrain All Wheel Drive
MSRP
$236,090
DetailsShow selling price
2026 Mercedes-Benz S-Class Maybach® S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class Maybach® S 580 4MATIC® Sedan
219 Interested, Peoria, AZ, 4.0L V8 Biturbo w/Mild-Hybrid -inc: ECO start/stop system, Maybach® S 580 4MATIC® Sedan, Automatic, # A17907, 9G-TRONIC 9-Speed Automatic, All Wheel Drive, 16/27 mpg
Engine 4.0L V8 Biturbo w/Mild-Hybrid -inc: ECO start/stop system
Transmission Description 9G-TRONIC 9-Speed Automatic
Drivetrain All Wheel Drive
Fuel Economy 16/27
MSRP
$239,635
DetailsShow selling price
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4725 North Scottsdale Road, Scottsdale, AZ 85251
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Sales: (480) 845-0012 | Hours
Service: (480) 845-0013 | Hours
Parts: (480) 845-0014 | Hours

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