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Home / 2025 Mercedes-Benz S 500 4MATIC vs. 2025 Mercedes-Benz S 580e 4MATIC

2025 Mercedes-Benz S 500 4MATIC vs. 2025 Mercedes-Benz S 580e 4MATIC


front view of the 2025 Mercedes-Benz S-Class


If you want unprecedented luxury and advanced technology in a car, consider buying the 2025 Mercedes-Benz S 500 4MATIC and 2025 Mercedes-Benz S 580e 4MATIC.  At Mercedes-Benz of Scottsdale in Scottsdale, AZ, we can help you choose between these extraordinary S-Class sedans. Each delivers remarkable performance, cutting-edge design, and premium comfort, but few differences set them apart. Please keep reading to see the 2025 Mercedes-Benz S 500 4MATIC vs. 2025 Mercedes-Benz S 580e 4MATIC comparison from our team of experts.

View Our New S-Class Inventory

Featured vehicles

2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$128,355
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2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$133,490
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2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 500 4MATIC® Sedan
$134,335
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2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$139,780
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2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2025 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$140,830
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$141,815
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$145,965
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$146,865
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$147,495
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2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
2026 Mercedes-Benz S-Class S 580 4MATIC® Sedan
$150,295
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Performance Highlights

The S 500 4MATIC combines sophistication with power through its 3.0L inline-6 turbo engine and mild hybrid drive. With 442 horsepower and 413 lb.-ft of torque, this sedan delivers a dynamic and fuel-efficient driving experience. Its 9G-TRONIC automatic transmission ensures precise gear changes, while the ECO Start/Stop system boosts fuel savings during idle moments. In contrast, the S 580e 4MATIC raises the bar with plug-in hybrid technology. Its 3.0L inline-6 engine teams with an electric motor to achieve a robust 503 combined horsepower. Offering up to 47 miles of all-electric range, the S 580e allows for gas-free commuting. Its optional DC charging enables a quick recharge, from 10% to 80%, in just 20 minutes.

Aesthetic Excellence S-Class

Both sedans feature bold AMG-inspired styling, LED lighting, and optional Night Packages for a striking, sporty look. The S 500 4MATIC focuses on timeless elegance with its sleek contours and chrome accents, while the S 580e 4MATIC balances form and function with its power charging door and aerodynamic enhancements.

rear seat of the 2025 Mercedes-Benz S-Class


infotainment of the 2025 Mercedes-Benz S-Class

Interior Comfort and Technology Features

You will find luxurious appointments inside the 2025 Mercedes-Benz S 500 4MATIC and 2025 Mercedes-Benz S 580e 4MATIC. Standard heated 12-way power front seats with memory ensure optimal comfort, while ENERGIZING kinetics and optional active multicontour massage functions enhance well-being during drives. In both models, technology takes center stage with a 12.8-inch OLED touchscreen and a 12.3-inch digital instrument cluster. Optional 3D enhancements for the instrument cluster provide an engaging display of navigation and driver assistance features. Additionally, the S 580e’s hybrid-focused displays help manage battery performance efficiently.

2025 Mercedes-Benz S 500 4MATIC vs. 2025 Mercedes-Benz S 580e 4MATIC: Which S-Class Suits You?

Depending on your driving needs, you can choose between the 2025 Mercedes-Benz S 500 4MATIC and the 2025 Mercedes-Benz S 580e 4MATIC. The S 500 emphasizes traditional luxury and performance, while the S 580e offers eco-friendly efficiency without compromising power. Visit Mercedes-Benz of Scottsdale to explore both models and learn about them from our team in Scottsdale, AZ.


Interested in the 2025 Mercedes-Benz S-Class?

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